. Read more. A study conducted in basketball players over 6 weeks did not report adverse events.Zahedi 2013, Information is limited.Du 2013, Peng 2013 The oral median lethal dose (LD50) of anthraquinones in mice is approximately 9 g/kg body weight. So to be clear, is it 1 or 2 ‘500mg’ tablets of GDB’s Japanese Knotwood per day? Major constituent chemicals include quinines (eg, anthraquinone, naphthoquinone, phylloquinone) and emodin-type anthroquinones, stilbenes (eg, resveratrol, piceatannol polydatin), flavonoids (eg, quercetin, catechin, rutin), coumarins, lignans, and other compounds.Chen 2012, Du 2013, Hao 2012, Kirino 2012, Li 2013, Peng 2013, Piotrowska 2012, Shen 2011, Zhang 2012, Emodin and phsycion demonstrate anti-inflammatory effects.Shen 2011 The stilbene content, including resveratrol, resveratroloside, polydatin, and piceatannol, are responsible for observed antioxidant activity.Kirino 2012, Piotrowska 2012, Methods of identification have been published, including high-performance liquid chromatography and thin-layer chromatography, which are based on the content of emodin and polydatin (minimum concentrations of 0.6% and 0.15%, respectively, per the Chinese pharmacopoeia). I have a question about Artemisinin as part of a Lyme protocol. You may be aware that the herbicide, glyphosate is often used to remove Japanese knotweed. And personally, even when I’m sure that what I’m having is a Herxheimer reaction, I view it as a sign that I’ve overloaded my body and I need to back off and detox. Japanese knotweed is the plant source with the highest resveratrol content. Clinical evidence on which to base dosing guidelines is lacking. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural compound found in red grape skin, Japanese knotweed (polygonum cuspidatum), peanuts, blueberries and some other berries. A study among healthy volunteers found a decreased expression of modulators of inflammation in mononuclear cells following 6 weeks of P. cuspidatum extract daily containing resveratrol 40 mg.Ghanim 2010 A small study (N = 20) found decreased plasma TNF-alpha and IL-6 versus placebo.Zahedi 2013, In vitro studies have shown broad antibacterial and antifungal activity of P. cuspidatum extracts.Peng 2013, Piotrowska 2012, Song 2006 Activity against Streptococcus mutans has been investigated in oral health.Ban 2010, Pandit 2012 An ethanol extract showed inhibitory activity against HIV-1 in vitro.Lin 2010, Peng 2013. Chilly April days have been spent harvesting and processing large, gorgeous, deep orange, potent, Japanese Knotweed rhizomes, collected from a select and pristine location in the heart of Vermont. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Studies indicate the most beneficial use to be in pancreatic, breast, and ovarian cancers. My daughter has been taking Artemisinin SOD Multi-Functional Formula by Researched Nutritionals. Japanese Knotweed (Fallopia japonica, or You Ji Hu Zhang in Chinese) is native to eastern Asia. We comply with the HONcode standard for trustworthy health information -. Bailey, and Reynoutria japonica Houtt. The supplement contains Artemisinin 250 mg, and Pro SOD Complex 550 mg Curcuwin Turmeric extract, Quercetin, Decaf Green Tea 95% extract, Black Walnut Hull. A one ounce bottle contains about 29-30 dropperfuls, thus if taking 35-40 drops (one dropperful) per day, a one ounce bottle will last about one month. my sister is pushing this for me to try as she is not responding to the doxycycline. We do not do this to track individual users or to identify them, but to gain useful knowledge about how the site is used so that we can keep improving it for our users. For example: If the dog weighs 50 pounds, the dose would be 1/3 of what is recommended for adults. Pets LOVE the taste! Glyphosate, widely sold under the brand names, Roundup and Rodeo, can be applied as a foliar spray (i.e., you spray it on the leaves) to stands of Japanese knotweed, using a pressurized garden sprayer. Most of the effects of Japanese Knotweed can be traced back to either the stilbenes (resveratrol) or the anthraquinones (emodin) for the circulatory and gastrointestinal help, respectively. My suspicion is that his reaction is due to these other things and has nothing to do with the Lyme. This content does not provide dosage information, format recommendations, toxicity levels, or possible interactions with prescription drugs. we tried half a capsule, and it was too much, I tried again, giving him less than half a capsule, and it is still to much. Japanese Knotweed Ltd does use some non-essential cookies. It is most famously known for containing high amounts of resveratrol. 1 loose tsp of this is just under 2 grams. Cat’s Claw vine bark – 500 mg. (Uncaria tomentosa) – wildharvested – Peru The assistance of a qualified health care provider familiar with all dosage outlines, contraindications, and herb/drug interactions outlined in Healing Lyme, and familar with your personal health history and current symptoms is strongly suggested. Hi Melissa, Do not use if pregnant, during breastfeeding or attempting to get pregnant. From a more Western point of view, polygonum is high in resveratrol. For information specific to the activity of resveratrol, see Resveratrol. Japanese knotweed root (Polygonum cuspidatum) – • Root powder: 1 tsp – 1 TBS 3x daily. The plant is native to eastern Asia, including Japan, China, and Korea. Green Dragon’s bottle of LB Core Protocol say they base their formula on your book. The adult dosage is 1 tsp-1 TBS of the powder 3x day. Avoid use during lactation; information regarding use during lactation is lacking. Dosage: Just use 1/2 tsp per 10 lbs of body weight. Nothing in this column is intended to replace the expertise and care of a qualified health care practitioner. . Finally bought an ounce of loose, Japanese Knotweed powder after contracting Lyme over a year ago. Yes, there are Herxheimer reactions when treating Lyme, but don’t assume that Lyme die off is the cause of every adverse reaction. Antioxidants neutralize free radicals, which are believed to be the cause of aging. Last updated on Dec 25, 2019. Approaching these tasks with gratitude, awareness of, and appreciation for the wisdom of this plant, and the wisdom of nature, is important to me. It is a powerful antioxidant produced by some plants to protect them against environmental stresses. Hi Patty, The material is intended for educational purposes only. BioPure Japanese Knotweed from Polygonum cuspidatum, also known as Japanese Knotweed, or by the Mandarin Chinese name of Hu Zhang, is native to Asia, and is a robust perennial in the Buckwheat family. The green dragon botanical website shipping costs to canada are out of this world. The assistance of a qualified health care provider familiar with all dosage outlines, contraindications, and herb/drug interactions outlined in Healing Lyme, and familar with your personal health history and current symptoms is strongly suggested.Nothing in this column is intended to replace the expertise and care of a qualified health care practitioner. For example, in Chinese medicine, herbs are prescribed based on the patient’s presentation, and many people would not be given this herb. Each individual is unique and what works for one person may not work for another. 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